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1) What is Slynd®?

Slynd® is a birth control pill (oral contraceptive) also called a POP (progestin only pill) that is used by females who can become pregnant to prevent pregnancy. 

2) How does Slynd® work for contraception?

Slynd® is effective at preventing pregnancy. Your chance of getting pregnant depends on how well you follow the directions for taking your birth control pills. The better you follow the directions, the less chance you have of getting pregnant. Based on the results of one clinical study of a 28-day regimen of Slynd® about 4 out of 100 females may get pregnant within the first year they use Slynd®.

3) Who should not take Slynd®?

You should not take Slynd® if you have kidney disease or kidney failure, reduced adrenal gland function (adrenal insufficiency), cervical cancer or any cancer that is sensitive to female hormones, liver disease, including liver tumors or unexplained vaginal bleeding. Tell your healthcare provider if you have or have had any of these conditions. Your health-care provider can suggest a different method of birth control.

4) How should I take Slynd®?

Slynd® (white active and green inactive tablets) is swallowed whole once a day. Take one tablet daily for 28 consecutive days; one white active tablet daily during the first 24 days and one green inactive tablet daily during the 4 following days. Tablets must be taken every day at about the same time of the day so that the interval between two tablets is always 24 hours.

5) When can I start taking Slynd®?

If you start taking Slynd® and you are not currently using a hormonal birth control method:
• Start Slynd® on the first day (Day 1) of your natural menstrual period (Day 1 Start). Your healthcare provider should tell you when to start taking your birth control pill.

If you start taking Slynd® and you are switching from another birth control pill:
• Start your new Slynd® blister pack on the same day that you would start the next pack of your previous birth control method.
• Do not continue taking the pills from your previous birth control pack.

If you start taking Slynd® and you are switching from a vaginal ring or transdermal patch:
• Start taking Slynd® on the day you would have inserted the next ring or applied the next patch.

If you start taking Slynd® and you are switching from a progestin only method such as an implant or injection:
• Start taking Slynd® on the day of removal of your implant or on the day when you would have had your next injection.

If you start taking Slynd® and you are switching from an intrauterine device or system (IUD or IUS):
• Start taking Slynd® on the day of removal of your IUD or IUS.

6) What if I want to become pregnant?

  • You may stop taking Slynd® whenever you wish. Consider a visit with your healthcare provider for a pre-pregnancy checkup before you stop taking Slynd®.

7) What are possible serious side effects of Slynd®?

Slynd® may cause serious side effects, including high potassium levels in your blood (hyperkalemia). Certain medicines and conditions can also increase the potassium levels in your blood. Your healthcare provider may check the potassium levels in your blood before and during treatment with Slynd®.

8) What are the most common side effects of Slynd®?

The most common side effects of Slynd® include acne, menstrual cramps, headache, nausea, breast pain and tenderness, severe vaginal bleeding, weight gain and less sexual desire. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

9) What should I know about my period when taking Slynd®?

Some women may miss a period. Irregular vaginal bleeding or spotting may happen while you are taking Slynd®, especially during the first few months of use. If the irregular vaginal bleeding or spotting continues or happens again after you have had regular menstrual cycles call your healthcare provider. It is important to continue taking your pills on a regular schedule to prevent a pregnancy.

10) What if I miss my scheduled period when taking Slynd®?

Some women miss periods on hormonal birth control, even when they are not pregnant. However, if you go 2 or more months in a row without a period, or you miss your period after a month where you did not use all of your Slynd® correctly, call you healthcare provider because you may be pregnant. Also call your healthcare provider if you have symptoms of pregnancy such as morning sickness or unusual breast tenderness. You should stop taking Slynd® if you are pregnant.

11) What should I do if I miss any Slynd® pills?

If one white active tablet is missed, take the missed tablet as soon as possible. Continue taking one tablet a day until the pack is finished. If two or more white active tablets are missed, take the last missed tablet as soon as possible. Continue one tablet a day until the pack is finished (one or more missed tablet(s) will remain in the blister pack).

References (click to expand)

1. Villavicencio J, Allen RH. Unscheduled bleeding and contraceptive choice: increasing satisfaction and continuation rates. Open Acc J Contracept. 2016;7:43-52. doi: 10.2147/OAJC.S85565
2. Slynd [package insert]. Exeltis USA, Inc.; Florham Park, NJ; 2019.
3. Data on file. Exeltis USA, Inc.; Florham Park, NJ; 2019.
4. Fuhrmann U, Krattenmacher R, Slater ED, et al. The novel progestin drospirenone and its natural counterpart progesterone: biochemical profile and antiandrogenic potential. Contraception. 1996;54(4):243-251
5. Regidor PA, Schindler AE. Antiandrogenic and antimineralocorticoid health benefits of COC containing newer progestins: dienogest and drospirenone. Oncotarget. 2017:8 (47): 83334-83342.
6. Vroonen L, Cavalier E, Vranken L, et al. Influence of drospirenone on renin-angiotensin-aldosterone system evaluation. Endocrine Abstracts. 2011;26:12.
7. Slopien R, Milewska E, Rynio P, et al. Use of oral contraceptives for management of acne vulgaris and hirsutism in women of reproductive and late reproductive age. Menopause Review. 2018;17(1):1-4. doi: 10.5114/pm.2018.74895
8. Greer JB, Modugno F, Allen G, et al. Androgenic progestins in oral contraceptives and the risk of epithelial ovarian cancer. Obstet Gynecol. 2005;105:731-740.
9. Batur P. Female contraception. Cleveland Clinic Center for Continuing Education. Published December 2016.
10. Glisic M, Shahzad S, Tsoli S, et al. Association between progestin-only contraceptive use and cardiometabolic outcomes: a systematic review and meta-analysis Eur J Prev Cardiol. 2018;25(10):1042-1052. doi: 10.1177/2047487318774847.
11. Duijkers IJM, Heger-Mahn D, Drouin D, et al. Maintenance of ovulation inhibition with a new progestogen-only pill containing drospirenone after scheduled 24-h delays in pill intake. Contraception. 2016:93(4): 303-309.


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